Table 2.

Multivariate linear regression of stroke severity (NIHSS) in all included ischemic stroke patients and in all ischemic stroke patients with modeled DOAC concentration at the event

Variable	NIHSS
	All included ischemic stroke patients (n=157)			Ischemic stroke patients with extrapolated DOAC concentration at the event (n=131)
	Slope	95% CI	P	Slope	95% CI	P
Low DOAC exposure*	3.161	0.741 to 5.581	0.011	-	-	-
Low DOAC concentration at event*	-†	-	-	1.570	–1.320 to 4.334	0.293
Female sex	–2.708	–5.125 to –0.291	0.028	–2.559	–5.398 to 0.281	0.077
Age	0.076	–0.053 to 0.205	0.246	0.099	–0.060 to 0.257	0.220
Hypertension	0.103	–3.717 to 3.924	0.957	0.379	–3.875 to 4.633	0.860
Diabetes mellitus	0.380	–2.312 to 3.072	0.781	0.154	–3.214 to 3.522	0.928
Hypercholesterolemia	–1.629	–4.039 to 0.780	0.183	–1.454	–4.318 to 1.409	0.317
Previous stroke/TIA	1.737	–0.769 to 4.243	0.173	1.661	–1.322 to 4.644	0.272
Congestive heart failure	1.001	–1.924 to 3.927	0.500	1.119	–2.383 to 4.622	0.528
Vascular disease	1.212	–1.292 to 3.717	0.340	1.354	–1.648 to 4.356	0.374
Large vessel occlusion	7.773	5.449 to 10.098	<0.001	7.597	4.796 to 10.397	<0.001
Atrial fibrillation	2.285	–1.687 to 6.257	0.257	1.936	–2.977 to 6.850	0.437

NIHSS, National Institutes of Health Stroke Scale; DOAC, direct oral anticoagulant; CI, confidence interval; TIA, transient ischemic attack.

^*Derived from ratios normalized to reference populations;

^†No published data available for comparison.