Table 5.
Logistic models on ARDS, severe COVID-19 and in-hospital mortality, overall and in the subset of male and female patients.
| Overall Model | ARDS | SEVERE COVID | IN-HOSPITAL MORTALITY | |||
|---|---|---|---|---|---|---|
| ODDS RATIO (95%CI) | P-value | ODDS RATIO (95%CI) | P-value | ODDS RATIO (95%CI) | P-value | |
| N=117/120 | N=118/120 | N=118/120 | ||||
| Sex: Male vs Female | 3.151 (1.050-9.459) | 0.0407 | 3.068 (0.516-18.226) | 0.2176 | 1.823 (0.488-6.806) | 0.3719 |
| Testosterone | 0.849 (0.734-0.982) | 0.0274 | 0.691 (0.546-0.874) | 0.0021 | 0.742 (0.566-0.972) | 0.0300 |
| Estradiol | 0.979 (0.957-1.002) | 0.0694 | 1.079 (1.000-1.164) | 0.0504 | 1.051 (1.018-1.084) | 0.0020 |
| Progesterone | 1.636 (0.462-5.793) | 0.4451 | 1.055 (0.580-1.920) | 0.8609 | 0.136 (0.005-3.527) | 0.2298 |
| Age | 1.022 (0.979-1.068) | 0.3194 | 1.028 (0.970-1.089) | 0.3525 | 1.141 (1.065-1.223) | 0.0002 |
| N. of comorbidities | 1.188 (0.868-1.626) | 0.2830 | 1.286 (0.858-1.926) | 0.2234 | 1.000 (0.690-1.450) | 0.9994 |
| Pneumonia at entry | 13.013 (3.348-50.575) | 0.0002 | 7.758 (1.927-31.236) | 0.0039 | 1.700 (0.409-7.057) | 0.4653 |
| Model on males | N=67/68 | N=67/68 | N=67/68 | |||
| Testosterone | 0.874 (0.763-1.000) | 0.0501 | 0.617 (0.347-0.872) | 0.0062 | 0.705 (0.519-0.959) | 0.0258 |
| Estradiol | 0.999 (0.967-1.033) | 0.9610 | 1.112 (0.965-1.281) | 0.1424 | 1.068 (1.010-1.129) | 0.0219 |
| Progesterone | 1.107 (0.323-3.801) | 0.8713 | 0.382 (0.100-1.462) | 0.1599 | <0.001 (<0.001-1.395) | 0.0603 |
| Age | 1.000 (0.948-1.054) | 0.9920 | 1.017 (0.929-1.113) | 0.7181 | 1.145 (1.044-1.256) | 0.0042 |
| N. of comorbidities | 1.541 (1.018-2.334) | 0.0411 | 2.153 (1.006-4.607) | 0.0482 | 1.196 (0.713-2.006) | 0.4972 |
| Pneumonia at entry | 24.921 (1.684-368.755) | 0.0193 | 1.001 (0.061-16.309) | 0.9994 | ||
| Model on females | N=51/52 | N=51/52 | N=51/52 | |||
| Testosterone | 0.445 (0.067 - 2.960) | 0.4020 | 0.524 (0.182 - 1.506) | 0.2300 | 0.578 (0.121 - 2.759) | 0.4914 |
| Estradiol | 0.962 (0.906 - 1.022) | 0.2090 | 1.076 (0.959 - 1.207) | 0.2101 | 1.058 (1.007 - 1.111) | 0.0245 |
| Progesterone | 2.724 (0.223 - 33.322) | 0.4329 | 1.245 (0.341 - 4.544) | 0.7405 | 0.144 (0.026 - 0.791) | 0.0258 |
| Age | 1.034 (0.962 - 1.112) | 0.3593 | 1.030 (0.948 - 1.120) | 0.4832 | 1.169 (1.030 - 1.328) | 0.0158 |
| N. of comorbidities | 0.812 (0.481 - 1.372) | 0.4374 | 1.050 (0.571 - 1.932) | 0.8747 | 0.976 (0.514 - 1.854) | 0.9416 |
| Pneumonia at entry | 8.808 (1.597 - 48.581) | 0.0125 | 4.313 (0.775 - 24.004) | 0.0951 | 2.000 (0.319 - 12.556) | 0.4594 |