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. 2022 Jan 27;12:811374. doi: 10.3389/fonc.2022.811374

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Copyright © 2022 Fan, Zhang, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the effects of nuclear lncRNAs through epigenetic modifications and transcription factors in CRCSCs and the downstream pathways and mediators involved. (1) LncRNAs can modulate transcription by transcription factors (TF) (2) LncRNAs can regulate DNA and histone modifying proteins by recruiting chromatin remodeling complexes.