Figure 7.

Effects of EH on the apoptotic rate in cardiomyocytes. To further demonstrate the effects of EH on apoptosis in cardiomyocytes, we first pre-incubated cardiomyocytes with UFH (200 μg/mL) for half an hour in the UFH group, followed by EH (100 μg/mL) or EH + LPS (1 μg/mL) stimulation. UFH can protect cardiomyocytes against apoptosis induced by EH in the presence or absence of LPS. Values are presented as the mean ± SD (n=3-5). EH, extracellular histones; UFH, unfractionated heparin; LPS, lipopolysaccharides *P<0.05 vs. control group, #P<0.05 vs. designated EH or EH + LPS group.