Table 1.
Echocardiography data of various changes in CLP mice
| 6 hours | 24 hours | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| sham | CLP | CLP + UFH | sham | CLP | CLP + UFH | |
| HR, beats/min | 368±24 | 384±5 | 375±35 | 396±23 | 388±59 | 392±32 |
| Wall measurements | ||||||
| IVS-diastole, mm | 0.69±0.12 | 1.02±0.18* | 0.93±0.14 | 0.73±0.17 | 0.74±0.07 | 0.93±0.22 |
| IVS-systole, mm | 1.12±0.06 | 2.03±0.88* | 1.44±0.18 | 1.05±0.27 | 1.33±0.20 | 1.41±0.25 |
| LVPW-diastole, mm | 0.73±0.12 | 0.85±0.12* | 0.66±0.09 | 0.83±0.12 | 0.77±0.17 | 0.93±0.14 |
| LVPW-systole, mm | 1.05±0.15 | 1.34±0.21* | 1.00±0.26# | 1.17±0.24 | 1.28±0.22 | 1.26±0.23 |
| LVID-diastole, mm | 3.57±0.20 | 2.93±0.45* | 3.27±0.15 | 3.57±0.13 | 3.12±0.35 | 2.84±0.34 |
| LVID-systole, mm | 2.26±0.10 | 1.53±0.42* | 1.95±0.28 | 2.72±0.39 | 1.54±0.15 | 1.62±0.56 |
| Cardiac function | ||||||
| EF, % | 62.57±3.47 | 83.53±9.99 | 73.14±9.36 | 52.19±0.83 | 82.73±6.03* | 70.28±15.09 |
| FS, % | 31.05±5.66 | 52.60±12.22 | 46.60±9.02 | 35.53±12.39 | 50.16±2.26 | 41.82±13.79 |
| LVEDV, μl | 62.51±2.87 | 30.30±8.16* | 42.96±6.35# | 51.62±9.26 | 33.44±1.77 | 35.36±7.43 |
| LVESV, μl | 24.66±5.41 | 5.06±3.95 | 11.94±5.36 | 25.85±3.12 | 5.72±0.16 | 12.19±7.81 |
| CO, ml/min | 13.96±1,85 | 9.68±2.73 | 11.64±1.16 | 10.26±3.03 | 12.40±1.82 | 8.46±1.41 |
| SV, μl | 37.86±2.55 | 25.24±7.37 | 31.02±1.35 | 25.77±6.13 | 31.98±0.20 | 23.37±2.34 |
| Doppler imaging | ||||||
| IVRT, ms | 12.43±1.44 | 27.22±4.43* | 15.83±9.85# | 15.73±2.87 | 16.48±1.76 | 17.08±3.45 |
| IVCT, ms | 9.48±3.98 | 7.04±2.00 | 10.83±2.08 | 13.69±2.58 | 8.47±3.99 | 10.60±1.69 |
| ET, ms | 53.21±3.31 | 54.11±2.72 | 62.25±4.63 | 54.19±2.16 | 41.39±8.09 | 56.31±6.94 |
| Tei index | 0.38±0.15 | 0.69±0.11* | 0.43±0.07# | 0.55±0.08 | 0.60±0.09 | 0.47±0.09 |
| E/A ratio | 2.31±0.35 | 1.47±0.14* | 1.59±0.23# | 1.86±0.37 | 1.50±0.03 | 1.64±0.22 |
Data presented as mean ± SE, n=4-6;
*
P<0.05 vs. corresponding sham;
#
P<0.05 vs. corresponding CLP.
HR: heart rate; IVS: interventricular septum; LVPW: left ventricular posterior wall; LVID: left ventricular interior diameter; EF: ejection fraction; FS: fraction shortening; LVEDV: left ventricular end diastolic volume; LVESV: left ventricular end systolic volume; CO: cardiac output; SV: stroke volume; IVRT: isovolumic relaxation time; IVCT: Isovolumic contraction time; ET: ejection time; CLP: cecal ligation and perforation.