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. 2022 Jan 15;14(1):120–134.

Figure 4.

Figure 4

PIC attenuated HG/HL-induced monocyte adhesion to endothelial cells by decreasing endothelial permeability under glucolipotoxicity conditions. A, B. Effects of HG/HL or HG/HL+PIC on monocyte (THP-1) adherence to HUVECs. The arrow indicates adherent monocytes (THP-1) in HUVECs. C. TER assay showing an increase in endothelial cell permeability at 2 hours following HG/HL stimulation; this increase persisted through 24 hours and PIC inhibited glucolipotoxicity-induced endothelial hyperpermeability. D. Evans Blue-labelled BSA diffusion assay confirming the significant protective effect of PIC against endothelial cell permeability. E. Western blotting analysis demonstrating the effects of PIC on ICAM-1 levels following HG/HL. The ICAM-1 protein level is shown relative to GAPDH. Values are shown as means ± SD. ***P < 0.05, vs. control group; ###P < 0.05, vs. HG/HL treatment group. Scale bar: 200 μm for 4×.