| Haskell-Ramsay et al (2017)16
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Vitis labrusca. Purple Concord grape juice. 230 mL drink once only The active treatment consisted of 200 mL Welch’s® purple grape juice (based upon single-serving guidelines at the time of the study) plus 30 mL of Schweppes® blackcurrant flavor cordial (containing 14 kcal and 3.1 g sugar per 100 mL). Schweppes™ blackcurrant flavor cordial was added at different volumes to the active treatment The nutritional content of drink: 140.2 kcal, 33.9 g of sugar, 138.3 mg/L anthocyanin content, 1504.5 μg/mL phenolic content
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Sugar-matched intervention 230 mL drink containing 200 mL Welches white grape juice, 10 mL blackcurrant flavor, and 20 mL water The nutritional content of drink: 139.2 kcal, 33.9 g of sugar, 1.04 mg/L anthocyanin content, 135.1 μg/mL phenolic content
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Acute: 20 min |
| Bell et al (2020)17
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Vitis vinifera. 400 mg grape seed polyphenol extract delivered in capsule form (made of bovine gelatine), each matched for weight and containing 400 mg powder consumed once daily. The extract was a 400 mg mix of purified grape seed–derived polyphenolic extracts from Vitis vinifera (MegaNatural AZ; Polyphenolics Inc., Madera, CA, USA) containing catechin, epicatechin, proanthocyanins, and derivatives of catechin and epicatechin (epicatechin gallate) based on in-house analysis by Polyphenolics Inc.
The nutritional content of the capsule: the exact calorie content of each was unknown.
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Acute: 4–6 h
Chronic: 3 mo
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| Calapai et al (2017)18
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Vitis vinifera. 250 mg oral supplement, once daily 250 mg of Cognigrape (Bionap srl, Italy). The extract consisted of proanthocyanins (>9%) and anthocyanins as malvidin-3-glucoside (4%–5%) The nutritional content of the capsule: not reported
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Chronic: 3 mo |
| Lamport et al (2016)19
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Vitis labrusca. 355 ml juice, once daily
The nutritional content of the drink: 233 kcal, 59.5 g of carbohydrates, 54 g of sugars. 777 mg total polyphenolics as a gallic acid equivalent/355-mL daily serving (167 mg anthocyanins asmalvidin equivalent, and 334 mg proanthocyanins as catechin equivalent). Vitamin C was not present in the supplement.
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Energy, appearance, taste, volume, carbohydrate content, and all sugars matched intervention. The nutritional content of the drink: 233 kcal, 59.5 g of carbohydrates, 54 g of sugars. No vitamin C or polyphenols present
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Chronic: 3 mo |
| Krikorian et al (2010)20
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Vitis labrusca. juice 3 times a day A drink based on 100% Concord grape juice provided by Welch Foods, Inc. (Concord, MA, USA). The nutritional content of the drink: drink had 0.7 kcal/mL dosed on body weight (daily consumption between 6 and 9 mL/kg). No further details of the drink were provided.
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The drink contained no juice or natural polyphenol. However, it was formulated to look and taste like grape juice and to have the same carbohydrate composition and energy. The nutritional content of the drink: the drink had 0.7 kcal/mL dosed on body weight (daily consumption between 6 and 9 mL/kg).
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Chronic: 3 mo |
| Krikorian et al (2012)21
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Vitis labrusca. Dosed on body weight, juice 3 times a day A drink based on 100% Concord grape juice derived by hot press and pasteurized with no added ingredient provided by Welch Foods, Inc. (Concord, MA, USA) The nutritional content of the drink: 425 mg/L of anthocyanin content. 46% anthocyanins, 29% tartaric acid esters of hydroxycinnamates, and 10% procyanidins. No further information reported
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Drink matching the grape juice concerning color, taste, total calories, and sugar profile, with no juice or polyphenolic compounds The nutritional content of the drink: no further information reported
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Chronic: 4 mo |
| Bensalem et al (2019)22
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Vitis vinifera and Vaccinium angustifolium Aiton. 300 mg capsule twice daily (1 capsule at least 1 h after breakfast and 1 capsule at least 1 h after dinner) Nutritional content of the capsule: 300 mg of extract, including low-molecular weight polyphenols: 42.8 ± 2.8% of total flavonoids (flavan-3-ols, flavanols, and anthocyanins) including 22.9 ± 1.6% of flavan-3-ols monomers and 19.1 ± 7.3% of oligomers, 0.6 ± 0.2% of flavanols (quercetin and glycosylated derivatives), 0.13 ± 0.04% of anthocyanins (especially malvidin 3-glucoside), 1.8 ± 0.6% of phenolic acids (such as chlorogenic, gallic, and ferulic acids); and 0.04 ± 0.01% of stilbenes (resveratrol). Two capsules provided 258 ± 17 mg of flavonoids.
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A matched placebo capsule The nutritional content of the capsule: 300 mg of pure maltodextrin (ref Maltrin® M100), providing no polyphenol
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Chronic: 6 mo |
| Lee et al (2017)23
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Vitis vinifera. Freeze-dried powder twice daily Active grape formulation (the freeze-dried grape powder made of commercially grown fresh red, green, and blue-black California grapes 36 g p.o. bid reconstituted in 227 mL of water) The nutritional content of the powder: total polyphenol content is 495 mg/100 g. Packet composed of 36 g of either formulation twice/day (total of 72 g/day, equivalent to 3 standard servings of fresh grapes per day). 458.9 mg/kg of anthocyanin content. No other information provided.
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Chronic: 6 mo |
