Table 1.
Patient and tumor characteristics.
| Age < 70 (n = 2379) | Age ≥ 70 (n = 309) | Total (n = 2688) | |
|---|---|---|---|
| Trial, p < 0.001 [2] | |||
| RTOG 9003 | 869 (36.5%) | 207 (67.0%) | 1076 (40.0%) |
| RTOG 0129 | 673 (28.3%) | 48 (15.5%) | 721 (26.8%) |
| RTOG 0522 | 837 (35.2%) | 54 (17.5%) | 891 (33.1%) |
| Gender, p < 0.001 [3] | |||
| Male | 2011 (84.5%) | 229 (74.1%) | 2240 (83.3%) |
| Female | 368 (15.5%) | 80 (25.9%) | 448 (16.7%) |
| Race, p = 0.70 [3] | |||
| White | 1922 (80.8%) | 253 (81.9%) | 2175 (80.9%) |
| Non-white | 447 (18.8%) | 55 (17.8%) | 502 (18.7%) |
| Unknown | 10 (0.4%) | 1 (0.3%) | 11 (0.4%) |
| Zubrod performance status, p < 0.001 [4] | |||
| 0 | 1505 (63.3%) | 156 (50.5%) | 1661 (61.8%) |
| 1 | 844 (35.5%) | 132 (42.7%) | 976 (36.3%) |
| 2 | 30 (1.3%) | 21 (6.8%) | 51 (1.9%) |
| Smoking history: pack-years [1], p < 0.001 [4] | (n = 2054) | (n = 264) | (n = 2318) |
| Mean | 35.5 | 46.5 | 36.8 |
| Std. Dev. | 31.79 | 40.47 | 33.07 |
| Median | 31.75 | 49 | 33 |
| Min – Max | 0–247.5 | 0–224 | 0–247.5 |
| Q1 - Q3 | 7.5–52 | 8–66 | 7.5–54 |
| Primary site, p < 0.001 [2] | |||
| Oral cavity | 125 (5.3%) | 30 (9.7%) | 155 (5.8%) |
| Oropharynx | 1534 (64.5%) | 174 (56.3%) | 1708 (63.5%) |
| Hypopharynx | 216 (9.1%) | 45 (14.6%) | 261 (9.7%) |
| Larynx | 504 (21.2%) | 60 (19.4%) | 564 (21.0%) |
| p16 status, p < 0.001 [3] | (n = 1087) | (n = 107) | (n = 1194) |
| Negative | 537 (49.4%) | 73 (68.2%) | 610 (51.1%) |
| Positive | 550 (50.6%) | 34 (31.8%) | 584 (48.9%) |
| T stage, p = 0.72 [4] | |||
| T1 | 53 (2.2%) | 9 (2.9%) | 62 (2.3%) |
| T2 | 729 (30.6%) | 78 (25.2%) | 807 (30.0%) |
| T3 | 922 (38.8%) | 143 (46.3%) | 1065 (39.6%) |
| T4 | 674 (28.3%) | 79 (25.6%) | 753 (28.0%) |
| Tis | 1 (0.0%) | 0 (0.0%) | 1 (0.0%) |
| N stage, p < 0.001 [4] | |||
| Age < 70 (n = 2379) | Age ≥ 70 (n = 309) | Total (n = 2688) | |
|
| |||
| N0 | 387 (16.3%) | 88 (28.5%) | 475 (17.7%) |
| N1 | 351 (14.8%) | 51 (16.5%) | 402 (15.0%) |
| N2a | 217 (9.1%) | 24 (7.8%) | 241 (9.0%) |
| N2b | 616 (25.9%) | 68 (22.0%) | 684 (25.4%) |
| N2c | 605 (25.4%) | 54 (17.5%) | 659 (24.5%) |
| N3 | 203 (8.5%) | 24 (7.8%) | 227 (8.4%) |
Std. Dev., standard deviation; Q1, first quartile; Q3, third quartile.
[1]
A pack-year is defined as the equivalent of smoking one pack of cigarettes a day for 1 year.
[2]
Pearson chi-square test.
[3]
Fisher’s exact test. Unknown race excluded.
[4]
Wilcoxon rank-sum test. Stage Tis excluded.