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Animal models used as tools in obesity and microbiome research. Animal models used in obesity and microbiome research (left panel). Methods employed to induce obesity and to manipulate the gut microbiota in animal models. Also indicated are the co-factors (variables) to take into account during the preclinical experiment on obesity and microbiota analysis (right panel). Abbreviation: DIO; diet-induced obesity, siRNA; small interfering ribonucleic acid.
