Skip to main content
. 2020 Dec 18;2020(12):CD008500. doi: 10.1002/14651858.CD008500.pub5

Comparison 5. Anticoagulants versus control: symptomatic deep vein thrombosis.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
5.1 Symptomatic DVT: DOAC vs placebo 3 1526 Risk Ratio (IV, Random, 95% CI) 0.51 [0.21, 1.22]
5.1.1 Apixaban 2 685 Risk Ratio (IV, Random, 95% CI) 0.27 [0.04, 1.73]
5.1.2 Rivaroxaban 1 841 Risk Ratio (IV, Random, 95% CI) 0.79 [0.41, 1.54]
5.2 Symptomatic DVT: LMWH vs no thromboprophylaxis 9 5408 Risk Ratio (IV, Random, 95% CI) 0.48 [0.35, 0.67]
5.2.1 Dalteparin 6 3063 Risk Ratio (IV, Random, 95% CI) 0.50 [0.32, 0.77]
5.2.2 Nadroparin 1 1150 Risk Ratio (IV, Random, 95% CI) 0.50 [0.19, 1.31]
5.2.3 Certoparin 1 883 Risk Ratio (IV, Random, 95% CI) 0.46 [0.18, 1.20]
5.2.4 Enoxaparin 1 312 Risk Ratio (IV, Random, 95% CI) 0.45 [0.22, 0.93]
5.3 Symptomatic DVT: prophylactic vs intermediate or therapeutic LMWH 1   Risk Ratio (IV, Fixed, 95% CI) Subtotals only
5.3.1 Prophylactic vs intermediate 1 51 Risk Ratio (IV, Fixed, 95% CI) Not estimable
5.3.2 Prophylactic vs therapeutic 1 52 Risk Ratio (IV, Fixed, 95% CI) 0.33 [0.01, 7.82]
5.4 Symptomatic DVT: LMWH vs aspirin 2 781 Risk Ratio (IV, Random, 95% CI) 0.81 [0.32, 2.04]
5.5 Symptomatic DVT: LMWH vs warfarin 1 439 Risk Ratio (IV, Fixed, 95% CI) 0.43 [0.17, 1.10]
5.6 Symptomatic DVT: semuloparin vs placebo 1 3212 Risk Ratio (IV, Fixed, 95% CI) 0.32 [0.16, 0.63]
5.7 Symptomatic DVT: vitamin K antagonists vs placebo 1 311 Risk Ratio (IV, Fixed, 95% CI) 0.08 [0.00, 1.42]
5.8 Symptomatic DVT: warfarin vs aspirin 1 440 Risk Ratio (IV, Fixed, 95% CI) 1.75 [0.75, 4.09]