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. 2020 Dec 18;2020(12):CD008500. doi: 10.1002/14651858.CD008500.pub5

Comparison 8. Anticoagulants versus control: clinically relevant bleeding.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
8.1 Clinically relevant bleeding: DOAC vs placebo 2 931 Risk Ratio (IV, Random, 95% CI) 1.61 [0.82, 3.15]
8.1.1 Apixaban 1 122 Risk Ratio (IV, Random, 95% CI) 1.87 [0.23, 14.91]
8.1.2 Rivaroxaban 1 809 Risk Ratio (IV, Random, 95% CI) 1.58 [0.78, 3.21]
8.2 Clinically relevant bleeding: LMWH vs no thromboprophylaxis 4 3105 Risk Ratio (IV, Random, 95% CI) 3.40 [1.20, 9.63]
8.3 Clinically relevant bleeding: prophylactic vs intermediate vs therapeutic LMWH 1   Risk Ratio (IV, Fixed, 95% CI) Subtotals only
8.3.1 Prophylactic vs intermediate 1 51 Risk Ratio (IV, Fixed, 95% CI) Not estimable
8.3.2 Prophylactic vs therapeutic 1 52 Risk Ratio (IV, Fixed, 95% CI) 0.33 [0.01, 7.82]
8.4 Clinically relevant bleeding: semuloparin vs placebo 1 3172 Risk Ratio (M‐H, Fixed, 95% CI) 1.40 [0.90, 2.19]
8.5 Clinically relevant bleeding: UFH vs no thromboprophylaxis 1 277 Risk Ratio (IV, Fixed, 95% CI) 2.01 [0.18, 21.96]