Fig. 2.

Linear correlation between peripheral immunity with cognition, neuroimaging and AD pathology. CN, cognitively normal; MCI, mild cognitive impairment; AD, Alzheimer’s disease; CSF, cerebrospinal fluid; Aβ, β-Amyloid; P-tau, phosphorylated-tau; T-tau, total tau; FDG-PET:18F-fluorodeoxyglucose-positron emission tomography; MMSE, Mini-Mental State; CDRSB, Clinical Dementia Rating Sum of Boxes; ADAS, Alzheimer’s Disease Assessment Scale; MEM, memory function; EF, executive function; HV, hippocampal volume; EC, entorhinal cortex; NEU, neutrophils; LYM, lymphocytes; NLR, neutrophil-lymphocyte ratio; 0.01 ≤ * ≤ 0.05, 0.001 ≤ ** < 0.01, 0.0001 ≤ *** < 0.001, **** < 0.0001