Comparison 1. Levodopa dose reduction (mg /day).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Levodopa dose reduction (mg/day)	11	2209	Mean Difference (IV, Fixed, 95% CI)	91.66 [79.12, 104.20]
1.1 Entacapone	5	837	Mean Difference (IV, Fixed, 95% CI)	55.44 [36.54, 74.33]
1.2 Tolcapone (50mg)	2	154	Mean Difference (IV, Fixed, 95% CI)	72.33 [27.87, 116.78]
1.3 Tolcapone (100mg)	3	394	Mean Difference (IV, Fixed, 95% CI)	155.71 [120.01, 191.41]
1.4 Tolcapone (200mg)	6	611	Mean Difference (IV, Fixed, 95% CI)	148.36 [122.88, 173.84]
1.5 Tolcapone (400mg)	3	213	Mean Difference (IV, Fixed, 95% CI)	55.43 [18.34, 92.52]