Comparison 2. 'Off' time reduction (hours).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Off time reduction (hours)	8	1584	Mean Difference (IV, Fixed, 95% CI)	1.30 [1.06, 1.55]
1.1 Entacapone	4	610	Mean Difference (IV, Fixed, 95% CI)	0.68 [0.22, 1.13]
1.2 Tolcapone (50mg)	2	154	Mean Difference (IV, Fixed, 95% CI)	1.41 [0.76, 2.05]
1.3 Tolcapone (100mg)	2	259	Mean Difference (IV, Fixed, 95% CI)	1.53 [0.90, 2.16]
1.4 Tolcapone (200mg)	4	413	Mean Difference (IV, Fixed, 95% CI)	1.63 [1.18, 2.09]
1.5 Tolcapone (400mg)	2	148	Mean Difference (IV, Fixed, 95% CI)	1.59 [0.91, 2.27]