Comparison 3. 'On' time increase (hours).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 'On' time increase (hours)	8	1663	Mean Difference (IV, Fixed, 95% CI)	1.47 [1.23, 1.71]
1.1 Entacapone	4	690	Mean Difference (IV, Fixed, 95% CI)	1.01 [0.62, 1.39]
1.2 Tolcapone (50mg)	2	154	Mean Difference (IV, Fixed, 95% CI)	1.64 [0.94, 2.34]
1.3 Tolcapone (100mg)	2	259	Mean Difference (IV, Fixed, 95% CI)	1.8 [1.12, 2.48]
1.4 Tolcapone (200mg)	4	412	Mean Difference (IV, Fixed, 95% CI)	1.91 [1.43, 2.38]
1.5 Tolcapone (400mg)	2	148	Mean Difference (IV, Fixed, 95% CI)	1.53 [0.80, 2.26]