Comparison 6. Adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Adverse events ‐ Dyskinesia	11	2537	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.09 [2.59, 3.69]
1.1 Entacapone	5	1134	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.23 [1.68, 2.96]
1.2 Tolcapone (50mg)	2	162	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.48 [1.79, 6.76]
1.3 Tolcapone (100mg)	3	394	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.96 [2.62, 6.00]
1.4 Tolcapone (200mg)	6	623	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.51 [3.23, 6.31]
1.5 Tolcapone (400mg)	3	224	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.02 [1.04, 3.91]
2 Adverse events ‐ Nausea	11	2537	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.27 [1.83, 2.82]
2.1 Entacapone	5	1134	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.93 [1.32, 2.80]
2.2 Tolcapone (50mg)	2	162	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.89 [1.15, 7.27]
2.3 Tolcapone (100mg)	3	394	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.03 [1.26, 3.26]
2.4 Tolcapone (200mg)	6	623	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.64 [1.80, 3.89]
2.5 Tolcapone (400mg)	3	224	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.80 [1.30, 6.05]
3 Adverse events ‐ Vomiting	7	1600	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.07 [2.48, 6.69]
3.1 Entacapone	2	465	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.16 [1.39, 12.50]
3.2 Tolcapone (50mg)	2	162	Peto Odds Ratio (Peto, Fixed, 95% CI)	5.60 [1.44, 21.81]
3.3 Tolcapone (100mg)	2	259	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.28 [1.40, 13.08]
3.4 Tolcapone (200mg)	5	490	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.67 [1.53, 8.78]
3.5 Tolcapone (400mg)	3	224	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.43 [0.91, 12.96]
4 Adverse events ‐ Diarrhoea	8	1807	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.31 [1.67, 3.19]
4.1 Entacapone	4	929	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.69 [1.67, 4.34]
4.2 Tolcapone (50mg)	1	83	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.13 [0.01, 1.30]
4.3 Tolcapone (100mg)	2	253	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.65 [0.76, 3.56]
4.4 Tolcapone (200mg)	4	397	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.52 [1.36, 4.65]
4.5 Tolcapone (400mg)	2	145	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.15 [0.97, 10.20]
5 Adverse events ‐ Constipation	7	1453	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.24 [1.46, 3.43]
5.1 Entacapone	3	637	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.27 [1.25, 4.13]
5.2 Tolcapone (50mg)	2	162	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.05 [0.15, 7.61]
5.3 Tolcapone (100mg)	1	135	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.72 [0.50, 5.87]
5.4 Tolcapone (200mg)	3	295	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.72 [1.14, 6.49]
5.5 Tolcapone (400mg)	3	224	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.59 [0.57, 11.67]
6 Adverse events ‐ Hallucinations	9	1976	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.78 [1.24, 2.58]
6.1 Entacapone	4	808	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.08 [0.56, 2.07]
6.2 Tolcapone (50mg)	2	162	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.06 [0.21, 5.39]
6.3 Tolcapone (100mg)	2	276	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.83 [0.80, 4.20]
6.4 Tolcapone (200mg)	5	506	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.65 [1.42, 4.96]
6.5 Tolcapone (400mg)	3	224	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.91 [0.87, 9.77]
7 Adverse events ‐ Dizziness	6	1210	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.99 [1.32, 2.98]
7.1 Entacapone	3	548	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.95 [1.15, 3.31]
7.2 Tolcapone (50mg)	1	83	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.96 [0.81, 78.76]
7.3 Tolcapone (100mg)	1	141	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.04 [0.74, 5.60]
7.4 Tolcapone (200mg)	3	293	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.45 [0.55, 3.85]
7.5 Tolcapone (400mg)	2	145	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.95 [0.41, 21.27]