UPDRS Motor section (Part III)
Study	Placebo	Entacapone	Tolcapone (50mg)	Tolcapone (100mg)	Tolcapone (200mg)	Tolcapone (400mg)
Entacapone
Brooks UK‐IRISH 2003	'On' state. Placebo n = 57	Entacapone n = 115; not significant
Myllyla FILOMEN 2001	'On' state. Placebo n = 108	Entacapone n = 218; P<0.01
Poewe CELOMEN 2002	'On' state. Placebo n = 88	Entacapone n = 172; P<0.01 (95% CI ‐5.13; ‐0.46)
PSG SEESAW 1997	'On' state. Placebo n = 102	Entacapone n = 103; P=0.02
Rinne NOMECOMT 1998	Placebo n = 86	Entacapone n = 85; P<0.05
Tolcapone (all doses)
Adler TFSGIII 1998	'On' state. Placebo n=72, least‐squares mean = ‐1.2 (SD 5.9)			Tolcapone 100mg n=69, least‐squares mean = ‐2.3 (SD 5.8); not significant	Tolcapone 200mg n=74 least‐squares mean = ‐2.4 (SD 6.0); not significant
Baas 1997	'On' state. Placebo n=58, least‐squares mean = ‐2.1 (SD 1.1)			Tolcapone 100mg n=60, least‐squares mean = ‐4.2 (SD1.0); not significant	Tolcapone 200mg n=59, least‐squares mean = ‐6.5 (SD 1.0); P<0.01
Dupont TIPSII 1997	Placebo n=33, least‐squares mean = ‐1.5 (SD 7.5)				Tolcapone 200mg n=32, least‐squares mean = ‐1.0 (SD 7.4); not significant	Tolcapone 400mg n=32, least squares mean = ‐1.0 (SD 7.9); not significant
Myllyla TIPS1 1997	'On' state. Placebo n=37, least‐squares mean = ‐0.3 (SD 10.3)		Tolcapone 50mg n=34, least squares mean ‐2.6 (SD 11.1); not significant		Tolcapone 200mg n=31, least‐squares mean ‐5.8 (SD 10.6); not significant	Tolcapone 400mg n=31, least squares mean = ‐3.7 (SD 11.1); not significant
Rajput 1997	'On' state. Placebo n=66, mean ‐0.4 (SD 7.3)			Tolcapone 100mg n=69, mean ‐1.9 (SD 7.5); not significant	Tolcapone 200mg n=67, mean ‐2.0 (SD 7.4); not significant