Table 1.

Descriptive statistics of demographic and genetic data of all patients with diagnosed childhood glaucoma

Number of patients, PCG/SCG	28; 11/17
Age at presentation
Mean ± SD (range), months	33.8 ± 36.5 (1–125)
Mean ± SD (range), years	2.8 ± 3 (0.07–10.41)
Age at time of suspected glaucoma diagnosis, months
Mean ± SD (range)	12.3 ± 24.9 (0–119.3)
Sex, n (%)
Female/Male	18 (64%)/10 (36%)
Country of origin, mother/father, n (%)
German	14 (50%)/14 (50%)
East European countries	5 (18%)/6 (21%)
Asia	7 (25%)/7 (25%)
Africa	2 (7%)/1 (4%)
Country of birth, n (%)
German	21 (75%)
East European countries	4 (14%)
Asia	3 (11%)
Laterality, n (%)
Unilateral/Bilateral	9 (32%)/19 (68%)
Unilateral/Bilateral, PCG	2 (18%)/9 (82%)
Unilateral/Bilateral, SCG	7 (41%)/10 (59%)
Mean number of performed eye surgeries	2 ± 3.7
Mean number of eye surgeries, performed at glaucoma department Mainz	2 ± 3.2
Positive family history, n (%)	6 (21%)
Consanguinity, n (%)	4 (14%)
Risk factors during pregnancy, n (%)
Smoking	2 (7%)
Alcohol drinking	3 (11%)
Genetic examination	24 (86%)
Revealed genes’ mutations with their type and location, n (%)	12 (50%) out of 24
CYP1B1 (2 compound heterozygous; 3 homozygous; 2p22.2)	5 (21%)
SOX11 (heterozygous; 2p25.2)	1 (4%)
TEK (heterozygous; 9p21.2)	1 (4%)
CRYBB3 (heterozygous; 22q11.23)	1 (4%)
FYCO1 (homozygous; 3p21.31)	1 (4%)
FOXC1 (heterozygous; 6p25.3)	1 (4%)
GJA8 (heterozygous; 1q21.2)	1 (4%)
LTBP2 (compound heterozygous; 14q24.3)	1 (4%)

SD, standard deviation; PCG, primary congenital glaucoma; SCG, secondary childhood glaucoma