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. 2022 Feb 10;10:19. doi: 10.1186/s40478-022-01323-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Deconvolving malignant cell states and their interaction with immune based clusters. A Differential distributions of IDH-WT specific malignant cell-states between the two immune-based survival groups are depicted by boxplots. B Scatter plots representing a positive correlation between the proportions of M0 macrophages and MES-like component of IDH-WT tumors across all 3 datasets. C Scatter plots representing a significant positive correlation between the expressions of OSM from macrophages and OSMR from malignant cells in IDH-WT tumors identified by scRNA based deconvolution. D Boxplots depicting differential distribution of epithelial-mesenchymal transition markers between the two immune-based survival groups. Similarly, E boxplots depicting differential distribution of STAT3 signaling markers between the two immune-based survival groups