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. Author manuscript; available in PMC: 2022 Feb 10.
Published in final edited form as: J Med Chem. 2019 Oct 15;62(20):9061–9077. doi: 10.1021/acs.jmedchem.9b00607

Scheme 4.

Scheme 4.

Synthesis of (R)- and (S)-4 and 5a

aReagents and conditions: (a) (1) 2-PrOH reflux, 3 h, (2) hydrazine, reflux, overnight; (b) indole-2-carboxylic acid, EDC/HOBt, DIPEA, CHCl3/DMF, 0 °C to rt, 8 h.