Figure 5.
Expression changes in EDC genes in psoriasis and in human evolution (A) A scatterplot showing gene expression differences observed between non-psoriatic human and chimpanzee skin on the x-axis, and plaque and non-plaque psoriatic skin on the y-axis. Genes are identified by significant (Padj < 0.05) differences in the human-lineage (blue) and psoriatic lesions (salmon). Two clusters with similar expression trends are marked by dotted rectangles. (B) The chromosomal location of EDC genes, where genes with significant human-lineage and psoriatic-expression differences match panel (A). Two EDC subclusters are indicated by dotted pink rectangles