TABLE 1.

List of the combinations tested, the molecular mechanisms identified for the observed synergy, and the setting where the treatments were performed.

Molecular rearrangement	Combination tested	Synergy	Molecular mechanism identified	In vitro drug treatment
				AML cell lines (SHI-1, NOMO-1, HL-60)	3D model
					AML cell lines (SHI-1, NOMO-1)	Ex vivo primary AML cells
KMT2A- rearranged AML	Venetoclax + I-BET151	Yes	Decreased BCL-2	X	X	X
	Venetoclax + sunitinib	Yes	Decreased MCL-1 and BCL-2	X	X	X
	Venetoclax + quinacrine	No	-	X	-	-
KMT2A-AFDN- rearranged AML	Venetoclax + thioridazine	Yes	Mitochondria depolarization	X	X	X
	Venetoclax + PD98059	No	-	X	-	-