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Future therapy strategies for LGMDR1. Calcium imbalance, thought to play a role in the pathophysiology of LGDMR1, can be repaired by inhibiting SERCA inhibitors through DWORF and by activating SERCA2 through CDN1163. ER stress can be reduced by targeting the degradation of proteins at the mRNA level through salubrinal and by preventing unfolded proteins associated with ER stress by means of TUDCA.
