Table 2.

Future therapy strategies.

	Type	Application	Expectation	Ref.
Mss51	Muscle-specific protein	Inhibition of Mss51 gene	Energy production increases and mitochondrial activity improves	[50]
TUDCA	The chemical chaperone mimetic drug	Different applications of TUDCA	Reduces effects on ER stress-related molecules	[65]
Salubrinal	A small molecule for selective inhibition of eIF2α	Different applications of salubrinal	Induces degradation of non-translated ER-targeted protein mRNAs	[66]
Rapamycin	Drug	Oral gavage	Provides inhibition of mTORC1, decrease in ER stress and inflammation, Improves muscle strength	[67]
CDN1163	A small molecule as a SERCA2 activator	Injected intraperitoneally	Reduces ER stress and maintains Ca+2 homeostasis	[71]
DWORF	Muscle-specific long non-coding RNA	Upregulate of DWORF gene	Inhibits SERCA inhibitors and increases SERCA activity	[73]