TABLE 2.

Toxicity researches of BBR.

Animals/cell lines	Dose	Administration method	Duration	Detail	Ref.
Fourth instar larvae	10 mg/L BBR plus near UVA	—	24 h	Decreased larval survival	Philogène et al. (1984)
Wistar and Sprague-Dawley rats	2, 10, 20 μg/g	intraperitoneal injection	7 days	Higher mean serum bilirubin concentration	Chan (1993)
Balb/c mice	10 mg/kg	intraperitoneal injection	14 days	Cellular and humoral immune functions suppression	Mahmoudi et al. (2016)
	5 mg/kg			Delayed-type hypersensitivity responses, lymphoproliferation
Zebrafish embryos	100 mg/L	—	24–96 h	Teratogenic effect, developmental toxicity, pericardial edema, cardiac looping defects, late heart morphogenesis impairment, early cardiac functionality impairment	Martini et al. (2020)
Cerebellar granule neurons, hippocampal neurons	0.01–10 µM		0.5–24 h	Severe disruption of neuritic and nuclear integrity, functional and morphological alterations of neuronal mitochondria	Kysenius et al. (2014)
Sprague-Dawley rat cardiomyocytes	10 μM	—	24 h	Cardiac arrest, total beating rate and amplitude inhibition	Zhang et al. (2018)

Note- :no relevant data.