Table 1.

Linear regression model representing the correlation of the single-nucleotide polymorphisms (SNPs) rs6675944 and rs12405889 in the tubulin-folding cofactor E (TBCE) gene with measures of vascular function and morphology from 4175 individuals in the Gutenberg Health-Study

SNP	Gene	bp	Phenotype	R  2	Beta	P-value
rs6675944	TBCE (intron) Chr1	233639292	FMD	0.006	−0.4841	5.92E−27
			Augmentation index	0.255	−0.135	0.61
			Stiffness index pre occlusion (m/s)	0.242	−0.0055	0.84
			Stiffness index post occlusion cc (m/s)	0.3	−0.0241	0.38
			Reflection index pre occlusion	0.145	−0.359	0.066
			Reflection index post occlusion	0.206	−0.46	0.028
			IMT (mm)	0.34	0.00262	0.053
rs12405889	TBCE (intron) Chr1	233663875	FMD	0.006	−0.5028	8.78E−25
			Augmentation index	0.257	0.0541	0.84
			Stiffness index pre occlusion (m/s)	0.242	0.00133	0.96
			Stiffness index post occlusion (m/s)	0.3	0.0176	0.53
			Reflection index pre occlusion	0.146	0.308	0.12
			Reflection index post occlusion	0.206	0.34	0.11
			IMT (mm)	0.34	−0.0022	0.12

bp, base pair; Chr1, chromosome 1; FMD, flow-mediated dilation; IMT, intima-media thickness. Bold values indicate significant values with P < 0.05.