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Schematic drawing of the structure of Lp(a). Lp(a) consists of LDL-like microparticles, a single apoB100 molecule, and apo(a). Apo(a) is composed of inactive protease P domain and cyclic domain. Heterogeneity in the number of KⅣ type 2 repeats accounts for different apo(a) isoforms. Except KⅣ2, which has multiple copies, the remaining domains are single copy. KⅤ, kringle ring structure Ⅴ; KⅣ, kringle ring structure IV.
