Table 1.

Baseline characteristics for studies of urinary glucose excretion assessment in patients with renal dysfunction.

Study (author, year)	Treatment	Renal dysfunction group	Definition of renal dysfunction	Number of participants
Devineni et al., 2015 (2)	Canagliflozin, 200 mg	Normal renal function	Creatine clearance, ≥80 ml/min	8
		Mild renal impairment	Creatine clearance, 50 to <80 ml/min	8
		Moderate renal impairment	Creatine clearance, 30 to <50 ml/min	8
		Severe renal impairment	Creatine clearance, <30 ml/min	8
Ikeda et al., 2019 (3)	Tofogliflozin, 20 mg	Normal renal function	eGFRa, >80 ml/min/1.73 m2	11
		Mild renal impairment	eGFRa, 50 to ≤80 ml/min/1.73 m2	8
		Moderate renal impairment	eGFRa, 30 to <50 ml/min/1.73 m2	9
		Severe renal impairment	eGFRa, <30 ml/min/1.73 m2	8
Macha et al., 2015 (4)	Empagliflozin, 50 mg	Normal renal function	eGFR, ≥90 ml/min/1.73 m2	8
		Mild renal impairment	eGFR, 60 to <90 ml/min/1.73 m2	9
		Moderate renal impairment	eGFR, 30 to <60 ml/min/1.73 m2	7
		Severe renal impairment	eGFR, <30 ml/min/1.73 m2	8
Sahasrabudhe et al., 2017 (5)	Ertugliflozin, 15 mg	Normal renal function	eGFR, ≥90 ml/min/1.73 m2	6
		Mild renal impairment	eGFR, 60 to <90 ml/min/1.73 m2	8
		Moderate renal impairment	eGFR, 30 to <60 ml/min/1.73 m2	8
		Severe renal impairment	eGFR, <30 ml/min/1.73 m2	6
Samukawa et al., 2018 (6)	Luseogliflozin, 5 mg	Normal renal function	eGFR, ≥90 ml/min/1.73 m2	11
		Mild renal impairment	eGFR, 60 to <90 ml/min/1.73 m2	17
		Moderate renal impairment G3a	eGFR, 45 to <60 ml/min/1.73 m2	10
		Moderate renal impairment G3b	eGFR, 30 to <45 ml/min/1.73 m2	13
		Severe renal impairment	eGFR, <30 ml/min/1.73 m2	6
Sarashina et al., 2014 (7)	Empagliflozin, 25 mg	Normal renal function	eGFR, ≥90 ml/min/1.73 m2	8
		Mild renal impairment	eGFR, 60 to <90 ml/min/1.73 m2	8
		Moderate renal impairment	eGFR, 30 to <60 ml/min/1.73 m2	8
		Severe renal impairment	eGFR, <30 ml/min/1.73 m2	8
Smulders et al., 2011 (8, 9)	Ipragliflozin, 50 mg	Normal renal function	eGFR, ≥90 ml/min/1.73 m2	8
		Mild renal impairment	eGFR, 60 to <90 ml/min/1.73 m2	9
		Moderate renal impairment	eGFR, 30 to <60 ml/min/1.73 m2	8
Veltkamp et al., 2011 (9, 10)	Ipragliflozin, 100 mg	Normal renal function	eGFR, ≥90 ml/min/1.73 m2	8
		Mild renal impairment	eGFR, 60 to <90 ml/min/1.73 m2	8
		Moderate renal impairment	eGFR, 30 to <60 ml/min/1.73 m2	8
		Severe renal impairment	eGFR, <30 ml/min/1.73 m2	8

eGFR, estimated glomerular filtration rate.

^aSince the renal function stratifications in this study basically matched with what we predefined, the data were also included in our analysis.