Table 2.
Clinical, laboratory, and histology data of patients who had undergone a diagnostic liver biopsy (histology cohort, n = 222) grouped according to low-density lipoprotein levels
| Variables | LDL < 50 mg/dL | LDL 51–130 mg/dL | LDL>130 mg/dL | P value |
|---|---|---|---|---|
| N (% of total) | 14 (6%) | 171 (77%) | 37 (17%) | N/A |
| Clinical data | ||||
| Age (y) | 12 ± 3 | 13 ± 3 | 14 ± 3 | .25 |
| Sex, N (%male) | 7, 50% | 115, 67% | 24, 65% | .45 |
| Ethnicity | ||||
| N (%) Hispanic | 3 (21%) | 40 (23%) | 3 (8%) | .12 |
| N (%) Non-Hispanic | 11 (79%) | 131 (77%) | 34 (92%) | |
| BMI (kg/m2) | 32.1 ± 5.1 | 35.5 ± 7.5 | 37.3 ± 6.9 | .05 |
| Laboratory values | ||||
| ALT (U/L) | 91 ± 47 | 96 ± 70 | 110 ± 64 | .22 |
| AST (U/L) | 52 ± 24 | 55 ± 35 | 64 ± 35 | .17 |
| GGT (U/L) | 55 ± 22 | 54 ± 56 | 81 ± 88 | <.01 |
| ALP (U/L) | 207 ± 66 | 213 ± 110 | 195 ± 117 | .45 |
| HbA1c% | 5.1 ± 0.4 | 5.3 ± 0.7 | 5.4 ± .1.0 | .81 |
| Histology data | ||||
| Steatosis | 2.4 ± 0.9 | 1.8 ± 1.0 | 2.0 ± 0.9 | .06 |
| Lobular inflammation | 1.3 ± 0.6 | 1.2 ± 0.7 | 1.0 ± 0.7 | .38 |
| Portal inflammation | 0.8 ± 0.6 | 0.8 ± 0.6 | 0.8 ± 0.6 | .88 |
| NAFLD activity score | 4.5 ± 1.3 | 3.7 ± 1.6 | 3.7 ± 1.6 | .14 |
| Fibrosis score | 1.0 ± 1.1 | 0.8 ± 1.0 | 0.8 ± 0.9 | .80 |
The results are shown as means ± standard deviation, unless otherwise indicated.