Table 2. Study characteristics sorted by descending enrollment period of birth cohort studies with approximately N = 26000 participants.
| REF | COUN-TRY | PARTICIPANTS (newborns) | ENROLLMENT PERIOD | SYMPTOM DIARY DURATION (from birth) | FOLLOW UP (FU) (without symptom diary) | QUESTIONNAIRE | CALLS/ INTERVIEW/ EMAIL | HOME-VISITS | CLINICAL VISITS/EXAMINATIONS | |
|---|---|---|---|---|---|---|---|---|---|---|
| PittsburghCohort(*)† | [42] | USA | n = 244 | 07/1985-04/1886 | until 3 yrs | every 2 wks | - | every 2 wks | - | - |
| Adelaide-Cohort (*)† | [38] | South AUS | n = 1981 | 05/1987 04/1988 |
until 2 yrs | after birth, once every 3 m until 24 m | 9 and 18 m | after delivery and discharge, then every 3 m until 2 yrs | - | - |
| New Mexico-Cohort(*)† | [11, 16, 36] | USA | n = 1205 χ [17] | 01/ 1988 06/1990 χ |
until 18 m | every 2 wks calls/ Interview | - | every 2 wks, up to age 18 m | at enrolment | - |
| Raine Study * | [43–46] | West AUS | n = 2868 χ [46] | 05/1989-11/1991 χ (53) | first y of life | 18, 34 wks gestation, birth, 1,2,3,5,8,10,14, 17,18,20,22,27 yrs | at age of 1, 2, 3, 4, 5, 8, 10, 14,17, 20 and 22, 27 yrs | telephone FU/ interviews ϕ | - | at age of 1, 2, 3, 5, 8, 10, 14, 17, 18, 20, 22 yrs |
| Perth-Cohort (*)† | [5, 47] | AUS | n = 263 | 07/1996-06/1998 | until 5 yrs | birth, 6 wks, 6, 12 m of age, then yl | not described in detail | telephone calls until resolution of the child’s symptoms | home visit for respiratory symptoms | at 6 wks, 6 and 12 m of age, and then yl |
| VIGALL (*) | [34] | NLD | n = 126 | 08/1996-11/1998 | wkly symptom card until 2 yrs | birth, 3m, 6m, 12m, 18m, 24m | birth, 3, 12, 24 m | - | during signs of URI | 6 m, 12 m, 18 m, 24 m |
| PEIC (*)‡ | [41, 48] | CAN | n = 332 | 06/1997 1999 |
until 2 yrs | twice mtly until 2 yrs | - | phoned twice mtly | - | - |
| Allergy-flora (*) | [49, 50] | SWE | n = 187 | 1998 2003 |
first y of life | 6, 12 m until 18 m Contact to parents at wk 1, 2, 4 and 8 until 2005 | - | at enrolment, then 6 and 12 m | - | at 18 m of age and if allergic symptoms occur |
| COPSAC 2000 (*) | [51, 52] | DK | n = 411 | 08/1998 12/2001 | until 6 yrs ϕ | 2, 4 wks ϕ, every 6 m until the age of 7 yrs, then at the age of 9, 12, 18 yrs | - | at enrolment, 1, 6, 12 m | - | at the age of 2 wks, every 6 m until the age of 7; if symptoms occur |
| WHIST-LER * | [53–57] | NLD | n = 2133 [58] | 12/2001-01/2013 | first y of life | at birth, mtly during the first 12 m, 5, 8 yrs | birth, mtly during first y, then yl | as reminder | to collect dust | 2nd or 3rd wk of life /FU 5 and 8 yrs |
| PASTURE (*) | [58–60] | AUT DEU FIN FRA CHE | n = 1133 | 08/2002 03/2005 |
2 m until 1 y | before birth 2, 12, 18, 24, 36, 48, 60, 72 m, at the age of 6 yrs, 10,5 yrs (until 2015) | before birth, 2, 12, 18, 24 m, and then yl until age of 6, 10,5 yrs | before birth, 2, 12, 18, 24 m, and then yl until age of 6 yrs | age of 2 m | age of 1y |
| Kopen-hagen-Cohort(*)† | [37, 61, 62] | DK | n = 242 χ | 05/2004 05/2005 |
first y of life | mtly until 1 y (1 May 2006) | - | at the first home visit, repeated every second m | mtly | mtly home visits |
| TEDDY Study * | [35, 63, 64] | USA/EUR | n = 8677 | 12/2004-02/2010 | 3 m until 2 yrs, then appropriate book | every 3 m until 4 yrs, then yl until the age of 15 yrs | 3, 9 m, up-dated after 2 yrs, then every 4 y | during visits biannually at 4 yrs of age | - | every 3 m until the age of 4yrs, then biannual, subgroup every 3 m |
| Madigan Childcare Study (*) ‡ | [65–67] | USA | n = 225 ¥ | 02/2006-04/2008 10/2008-06/2009 |
STA was completed by the child’s parent for 10 days following illness onset for 2 y | interviews until 40 m of age χ | - | at enrolment and if symptoms occurred | at illness onset | a study physician documented visit/ nurse contact in childcare site |
| Utrecht-Cohort (*)† | [68–71] | NLD | n = 291 χ (39) | 03/2006-02/2010χ | first y of life | 1 and 12 m | at 1m and 1 y of age | around birth, 3 wks after delivery | first respi-ratory infection | to withdraw blood at first m |
| STEPS * | [72–75] | FIN | n = 1827 | 01/2008-04/2010 | first two yrs of life daily, then wkly until 5 yrs of age | before and after birth, 13, 18, 24 m. until the age of 2 yrs | before birth, birth, 13, 18, 24 m, then yl | no | no | if symptoms occur/ age of 2, 13, and 24 m. |
| COPSAC 2010 * | [76] | DK | n = 700 | 2008/2010 | until 3 yrs ϕ | 24, 36 wks gestation,1 wk, 1, 3, 6 m, then every 6 m until 36 m, then yl until 6 yrs, then at the age of 8, 10 yrs | online survey from 2016 onwards ϕ | at regular intervals between visits | - | week 24 of gestation, 1, 3, 6 m, then every 6 m until 36 m, then yl until 7yrs; if symptoms occur |
| DIABIMMUNE | [77–80] | FIN EST RUS | n = 563 | 09/2008–10/2013 | 3m until 3 yrs | 3, 6, 12, 18, 24, 36 m | 3, 6, 12, 18, 24, 36 m | - | - | 3, 6, 12, 18, 24, 36-m |
| OrChid (*) | [12, 81–83] | AUS | n = 158 | 09/2010-10/2014 | until 2 yrs | every 3 m until 2nd birthday | no | telephone-interview 3‐mtly | no | after delivery |
| NPICS (*) | [39, 84] | NIC | n = 518 n = 1705 ¥ | 2011–2013 | until 2 yrs (subgroup) | until 2 yrs, wkly in diary subgroup | at enrollment, then yl. | yl calls and email as reminder | for part who did not attend FU | yl/ first signs of influenza-like illness |
| PATCH (*) | [85, 86] | TWN | n = 387 | 01/2012-11/2014 | first y of life | 1, 2, 4, 6, 12 m | at each planned visit | calls, interviews, emails | - | regular visits at clinic and examinations, if symptoms occur |
| Loewen KIDS * | [87] | DEU | n = 782 | 11/2014-02/2018 | until 6 yrs | at birth, 3,6,12,18, 24 m, then yl until age of 15 y | at birth, 6 m, age 1 till 15 yl. | email as reminder | no | to withdraw blood |
|
wk
wkly m mtly y yl part |
week
weekly months monthly year yearly participant |
¥ (*) * - χ † |
over all sample size
complete active data not reported varies according to publication if no study name was known the location of the primary centre is given |
‡
‡ Madigan Childcare-Study ‡PEIC URI ϕ - |
abbreviated cohort name
Madigan Army Medical Centre-Childcare Study Prince Eduard Island Cohort upper respiratory infection validated through study stuff- different to data in publication Data not reported |
|||||