Fig 6. Supermotif escape mutations.

(A) Influence of supermotif core position and residue conservation in the epitope escape capacity of substitutions. (B) Average percentage of escape supermotifs by any mutation type after incremental filter application. (C) Absolute number of mutated supermotifs for each supertype after incremental filter application. (D) Nightingale rose charts indicating the percentage of escape supermotifs in prevalent M49 zones. Only mutations involving ≥2 isolates in the M49 were considered. Only M49 zones with ≥ 5% escape supermotifs for at least one supertype are shown.