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. 2022 Jan 27;12:832835. doi: 10.3389/fonc.2022.832835

Table 2.

BIAS outcome details, pathological features and Xpert test results by active surveillance outcome.

Total Failure Not Failure Other p-value
    N = 139 N = 68 N = 65 N = 6
BIAS history, N (%) Already enrolled 61 (100) 30 (49.2) 27 (44.3) 4 (6.56) 0.494
Newly enrolled 78 (100) 38 (48.7) 38 (48.7) 2 (2.60)
AS outcome details, N (%) No more lesion 6 (100) n.r. 6 (100) n.r. <0.001
  On AS 55 (100) n.r. 55 (100) n.r.
  Death for other cause 6 (100) n.r. 4 (66.6) 2 (33.3)
  Lost at follow-up 4 (100) n.r. n.r. 4 (100)
  Increase in size 32 (100) 32 (100) n.r. n.r.
  Increased number 14 (100) 14 (100) n.r. n.r.
  Hematuria 6 (100) 6 (100) n.r. n.r.
  UC: positive\suspected 5 (100) 5 (100) n.r. n.r.
  Increased N° and size 3 (100) 3 (100) n.r. n.r.
  Increased size and Hematuria 5 (100) 5 (100) n.r. n.r.
  UC and Increase N° 1 (100) 1 (100) n.r. n.r.
  Increased size, hematuria & UC 1 (100) 1 (100) n.r. n.r.
  Voluntary withdrew 1 (100) 1 (100) n.r. n.r.
TURBT stage, N (%) Negative 9 (100) 9 (100) 0 (0.00) 0.89
  pTa 52 (100) 51 (98.0) 1 (2.00)
  pT1 3 (100) 3 (100) 0 (0.00)
TURBT grade, N (%) Low grade 46 (100) 45 (97.8) 1 (2.20) 0.66
  High grade 9 (100) 9 (100) 0 (0.00)
Xpert Xpert 1st point, N (%) Negative 57 (100) 20 (35.1) 36 (63.2) 1 (1.70) 0.005
  Positive 82 (100) 48 (58.5) 29 (35.4) 5 (6.10)
Xpert Xpert 2nd point, N (%) Negative 34 (100) 9 (26.5) 25 (73.5) 0.13
  Positive 12 (100) 6 (50.0) 6 (50.0)
Xpert Xpert 3rd point, N (%) Negative 25 (100) 4 (16.0) 21 (84.0) 0.39
  Positive 4 (100) 0 (0.00) 4 (100)
Xpert Xpert 4th point, N (%) Negative 25 (100) 3 (12.0) 22 (88.0)

AS, active surveillance; BIAS, Bladder Cancer Italian Active Surveillance; n.r., not reported; TUBRT, transurethral resection of bladder tumor; UC, urinary cytology.