Table 3.
PfCRT-K76T mutation and pfk13-propeller polymorphisms per site and per study
| Site | pfcrt-K72T | pfk13mutation | |||
|---|---|---|---|---|---|
| 2017-study n/N (%) |
2019-study n/N (%) |
p-value | 2017-study | 2019-study | |
| Bolenge | 18/56 (32.1) | 17/76 (22.4) | 0.21 | A578S | |
| Fungurume | 1/65 (1.5) | 1/69 (1.4) | 0.99 | A578S | A578S |
| Kalima | 3/66 (4.5) | 4/81 (4.9) | 0.99 | – | |
| Kamina | 8/71 (11.3) | 6/81 (7.4) | 0.42 | A569T | D584E, V568M |
| Karawa | 6/54 (11.1) | 11/83 (13.3) | 0.71 | – | D584E |
| Katana | 68/76 (89.5) | 64/76 (84.2) | 0.33 | M472I | S576T |
| Kinshasa | 78/160 (48.8) | 34/104 (32.7) | 0.01 | A578S | A578S, M472L |
| Kisangani | 4/85 (4.7) | 6/95 (6.3) | 0.89 | A578S | D516A |
| Lubumbashi | 1/56 (1.8) | 5/82 (6.1) | 0.43 | – | Y588C |
| Vanga | 31/75 (41.3) | 41/86 (47.7) | 0.42 | V534A | |
| Total | 218/764 (28.5) | 189/833 (22.7) | 0.007 | ||
Pf: Plasmodium falciparum, n: Number of isolates carrying K76T, N: Number of isolates successfully sequenced