Table 3.

Adjusted Odds Ratios of Developing AKI by Different Definitions/Populations

Age Bracket	Original	Full-Age Spectrum	Modified MDRD	No Pre-Existing Comorbidities
10–15-year-olds	2.74 (1.66–4.56)*	2.49 (1.47–4.22)**	2.66 (1.60–4.41)**	5.35 (2.42–11.81)*
40–45-year-olds	1.39 (0.97–2.00)	1.34 (1.00–1.80)***	1.48 (1.03–2.11)***	1.24 (0.65–2.37)
70–75-year-olds	2.31 (1.71–3.12)*	2.79 (2.09–3.94)*	2.48 (1.87–3.29)*	2.34 (1.13–4.84)***

Table presents snapshot of odds ratios (95% confidence intervals) for developing acute kidney injury (AKI) compared to 30–35-year-olds. Odds ratios adjusted for sex, race/ethnicity, hypertension, diabetes mellitus, cancer, chronic kidney disease, and severity of illness. Original column defines AKI per KDIGO guidelines when making assumptions about estimating a baseline creatinine. Full-age spectrum column defines AKI per KDIGO guidelines but assumes a more gradual change in eGFR across the age spectrum and uses the previously validated full age spectrum equation to estimate a baseline creatinine. Modified MDRD column defines AKI per KDIGO guidelines when making assumptions about estimating a baseline creatinine, but for adult patients does not include race as a variable in the MDRD equation. The final column only includes hospitalized patients with no pre-existing comorbidities, as such its adjustment model is limited to sex, race/ethnicity, and severity of illness

* p < 0.0001

**p < 0.001

***p ≤ 0.05