Table 2.

Comparison of hematologic findings in PNH patients and mouse models of PNH.

Findings	Hematopoietic mosaic mice generated by fetal liver cell transplant. Murakami et al. (1999) (40)	Hematopoietic mosaic LF female mice at 16 mos of age. Keller et al. (2001) (35)	Hematopoietic mosaic mice generated by fetal liver cell transplant with alloreactive CD4+ T cells. Murakami et al. (2002) (41)	Bone marrow failure with associated PNH clone (58, 59)	Classical PNH patients (58, 59)
Clonal expansion	No	No	Yes	Yes; mean granulocyte clone 11% (58, 59)	Yes, mean granulocyte clone >70% (58, 59)
Immune pressure	No	No	Yes	Yes	Yes
Hemolytic anemia	No	No	No	Varies	Yes
GPI (-) Myeloid cell	Stable ~20-30% engraftment	~50% GPI (-): GPI (+); no clonal expansion	Transient GPI (-) advantage post-BMT		Favors GPI (-)
GPI (-) T lymphocyte	Favors GPI (-)	Favors GPI (-)	Transient GPI (-) advantage post-BMT		Favors GPI (+)
GPI (-) B lymphocyte	Stable ~20-30% engraftment	<50% GPI (-); no clonal expansion	Transient GPI (-) advantage post-BMT		Favors GPI (+)
GPI (-) Red blood cells	Stable ~20-30% engraftment	~50% GPI (-): GPI(+) reticulocytes; no clonal expansion	ND		Favors GPI (-)

ND, not determined.