Table 1.
Mann–Whitney U tests for unpaired variables for group comparisons
| MS patients with IRLs | MS patients without IRLs | W | p value | Adjusted p value | |
|---|---|---|---|---|---|
| Mean age, years (SD) |
40.95 (10.12) |
35.67 (10.65) |
867.5 | 0.01 | 0.38 |
| Mean disease duration, years (SD) |
8.58 (8.85) |
3.48 (3.29) |
818.0 | 0.004 | 0.12 |
| Median EDSS, baseline (range) |
3 (0–6.5) |
1 (0–6) |
523.5 | < 0.001 | < 0.001 |
| Mean nCSA C1/2, mm2 (SD) |
65.14 (7.9) |
70.66 (7.49) |
1697.0 | < 0.001 | 0.02 |
| Mean volume, NAGM, mL (SD) | 739.74 (56.81) | 790.89 (53.57) | 1792.0 | < 0.001 | 0.002 |
| Mean volume, NAWM, mL (SD) | 722.43 (61.58) | 745.16 (49.54) | 1509.0 | 0.04 | 1 |
| Mean volume, thalamus, mL (SD) |
14.62 (2.20) |
15.52 (1.67) |
1578.5 | 0.01 | 0.29 |
| Mean volume, DGM, mL (SD) |
33.45 (4.52) |
35.32 (3.55) |
1542.0 | 0.02 | 0.58 |
| Mean T2-LV, mL (SD) |
9.39 (11.99) |
2.87 (5.34) |
480.5 | < 0.001 | < 0.001 |
| Mean T1-LV, mL (SD) |
2.29 (3.25) |
0.35 (0.72) |
482.5 | < 0.001 | < 0.001 |
| Mean number of cervical lesions (SD) |
2.34 (1.66) |
0.98 (1.29) |
641.0 | < 0.001 | < 0.001 |
| Mean cervical LV, mL (SD) |
0.96 (0.82) |
0.26 (0.42) |
510.0 | < 0.001 | < 0.001 |
Abbreviations: DGM, deep grey matter; EDSS, Expanded Disability Status Scale; IRLs, iron rim lesions; LV, lesion volume; NAGM, normal-appearing grey matter; NAWM, normal-appearing white matter; nCSA, normalised cross-sectional area; SD, standard deviation