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. 2022 Jan 28;13:821932. doi: 10.3389/fimmu.2022.821932

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Copyright © 2022 Liu, Yang, Chen, Chen, Wang, Lee, Zheng, Shang, Tang, Zhang, Hu, Huang, Peng, Liou, He and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The schematic diagram on how P311 enhances the wound healing capabilities of MSCs via the up-regulation VEGF expression mediated by mTOR signalling pathway. (A) P311-mediated anti-inflammatory effects attenuate the inflammatory status of wound tissues for wound healing. (B) Neo-vascularization of new blood vessels by the release of VEGF from MSCs with increased P311 levels that enhances their pro-angiogenesis function to accelerate skin wound healing. (C) Increased collagen deposition and elevated production of hydroxyproline by MSCs with increased P311 levels. (D) Increased P311 levels in MSC activates the mTOR signalling pathway, which in turn up-regulate the expression of VEGF, leading to their release from the MSCs to aid in enhanced wound healing process by MSCs. Collective functions of these processes mediated by P311 enhanced MSCs contributes to the overall quality of wound healing. Created with BioRender.com.