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. 2022 Jan 28;12:806844. doi: 10.3389/fphar.2021.806844

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Copyright © 2022 Chen, Wang, Tang, Yu, Lu, Zhang, Yan, Deng, Han, Li and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Punica granatum peel polysaccharides (PPPs) ameliorated imiquimod (IMQ)-induced psoriasis in BALB/c mice. Representative photographs of the dorsal skin in the IMQ-elicited psoriasis mouse model post-IMQ treatment without or with PPPs. (A) Psoriasis Area and Severity Index (PASI) scores of the skin lesions in mice with IMQ-elicited psoriasis post-treatment. (B) Transepidermal water loss (TEWL) of the skin lesions in IMQ-induced psoriasis-like mice. Data are presented as the mean ± SD (n = 6). ^# p < 0.05, ^## p < 0.01 vs. the control group; *p < 0.05, **p < 0.01 vs. the vehicle group. PPPs-L, low-dose PPPs; PPPs-H, high-dose PPPs.