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. 2022 Jan 28;12:806844. doi: 10.3389/fphar.2021.806844

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Copyright © 2022 Chen, Wang, Tang, Yu, Lu, Zhang, Yan, Deng, Han, Li and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological analysis and immunohistochemistry assay. Different treatments were administrated to mice. H&E staining (A) of the dorsal skin lesion in different groups. Immunohistochemical photographs of CD3 (B) and Ki67 (C) staining (magnification, ×100) of the dorsal skin in control or psoriatic mice post-treatment. The black arrows indicate the CD3 and Ki67 positive location. ##p < 0.01 compared with the control group; **p < 0.01 compared with the vehicle group. PPPs-L, low-dose PPPs; PPPs-H, high-dose PPPs.