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. 2022 Jan 28;12:806844. doi: 10.3389/fphar.2021.806844

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Copyright © 2022 Chen, Wang, Tang, Yu, Lu, Zhang, Yan, Deng, Han, Li and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Punica granatum peel polysaccharides (PPPs) decreased the levels of inflammatory mediators in mice with imiquimod (IMQ)-elicited psoriasis. The levels of the inflammatory mediators TNF-α (A), IL-6 (B), IL-23 (C), IL-17 (D), and IL-8 (E) were measured by ELISA in the serum of IMQ-induced psoriasis-like mice. Data are shown as the mean ± SD (n = 6). ^# p < 0.05, ^## p < 0.01 compared with the control group; *p < 0.05, **p < 0.01 compared with the vehicle group. PPPs-L, low-dose PPPs; PPPs-H, high-dose PPPs.