FIGURE 7.

Punica granatum peel polysaccharides (PPPs) suppressed aquaporin-3 (AQP3), filaggrin (FLG), and the NF-κB and STAT3 signaling pathways in skin with psoriatic lesions. Effect of PPPs on the translational expressions of p-NF-κB, NF-κB, p-STAT3, STAT3, AQP3, and FLG in the skin samples of mice with imiquimod (IMQ)-elicited psoriasis as determined by Western blotting post-treatment with PPPs. Densitometry analyses of the immunoblotting are shown as p-NF-κB/NF-κB (A), p-STAT3/STAT3 (B), AQP3/β-actin (C), and p-STAT3/β-actin (D). Data are shown as the mean ± SD (n = 3). ^# p < 0.05, ^## p < 0.01 vs. the control group; *p < 0.05, **p < 0.01 vs. the vehicle group. PPPs-L, low-dose PPPs; PPPs-H, high-dose PPPs.