TABLE 4.
Risk stratification by predicted genetic or environmental risk score for cholelithiasis at baseline.
| Regular use of PPI | Regular use of H2RA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Person-years | Incidence rate a | HR (95%CI) b | RD (95%CI) b | Cases | Person-years | Incidence rate a | HR (95%CI) b | RD (95% CI) b | |
| Stratified analysis by genetic risk score | ||||||||||
| Q1 | 455 | 114,981 | 3.96 | 1.32 (1.16,1.50) | 3.28 (2.32, 3.71) | 66 | 23,634 | 2.79 | 0.93 (0.72,1.20) | -1.42 (-11.7, 1.93) |
| Q2 | 531 | 118,062 | 4.50 | 1.29 (1.14,1.45) | 3.56 (2.39, 4.10) | 93 | 24,988 | 3.72 | 1.13 (0.91,1.40) | 1.92 (-2.44, 3.32) |
| Q3 | 568 | 113,913 | 5.00 | 1.34 (1.20,1.50) | 4.16 (3.26, 4.63) | 120 | 24,772 | 4.84 | 1.31 (1.08,1.59) | 3.92 (1.68, 4.64) |
| Q4 | 690 | 115,525 | 6.00 | 1.16 (1.04,1.28) | 3.34 (1.11, 4.55) | 151 | 25,490 | 5.92 | 1.23 (1.04,1.46) | 4.10 (1.10, 5.36) |
| P interaction | 0.223 | 0.337 | 0.15 | 0.288 | ||||||
| Stratified analysis by environmental risk score | ||||||||||
| Q1 | 21 | 17,533 | 1.20 | 1.49 (0.95, 2.32) | 1.15 (-0.48, 1.2) | 7 | 9,058 | 0.77 | 0.92 (0.4, 2.07) | -0.6 (-56.18, 0.77) |
| Q2 | 131 | 47,353 | 2.77 | 1.65 (1.35, 2.01) | 2.71 (2.41, 2.76) | 38 | 14,558 | 2.61 | 1.62 (1.16, 2.25) | 2.55 (1.60, 2.61) |
| Q3 | 353 | 110,383 | 3.20 | 1.31 (1.16, 1.49) | 2.66 (1.92, 3.01) | 80 | 25,467 | 3.14 | 1.2 (0.95, 1.51) | 2.15 (-1.05, 2.98) |
| Q4 | 1759 | 290,297 | 6.06 | 1.22 (1.15, 1.31) | 4.09 (3.24, 4.81) | 308 | 50,404 | 6.11 | 1.14 (1.01, 1.28) | 3.12 (0.30, 4.64) |
| P interaction | 0.068 | <0.001 | 0.362 | 0.926 | ||||||
| Stratified analysis by environmental and genetic risk score | ||||||||||
| Q1 | 29 | 21,036 | 1.38 | 1.72 (1.16, 2.55) | 1.37 (0.90, 1.38) | 6 | 9,422 | 0.64 | 0.92 (0.41, 2.07) | -0.51 (-48.31, 0.64) |
| Q2 | 134 | 53,495 | 2.51 | 1.72 (1.16, 2.55) | 2.47 (1.54, 2.50) | 35 | 15,704 | 2.23 | 1.43 (1.01, 2.03) | 2.07 (0.13, 2.22) |
| Q3 | 375 | 113,935 | 3.29 | 1.34 (1.18, 1.52) | 2.82 (2.12, 3.12) | 96 | 25,483 | 3.77 | 1.42 (1.15, 1.76) | 3.41 (2.14, 3.71) |
| Q4 | 1706 | 274,015 | 6.23 | 1.23 (1.15, 1.31) | 4.29 (3.32, 4.94) | 293 | 48,274 | 6.07 | 1.1 (0.97, 1.24) | 2.43 (-1.00, 4.29) |
| P interaction | 0.191 | <0.001 | 0.176 | 0.237 | ||||||
a
Per 100,000 person years.
b
Estimated effects were based on the fully adjusted model (see the footnote in Table 2).