Table 2.
Therapy-induced changes of laboratory and CMR parameters in patients with epirubicin-based chemotherapy
| Baseline (n = 39) | FU1 (n = 39) | FU2 (n = 38) | p value for FU1 vs. FU2 | |
|---|---|---|---|---|
| Laboratory tests | ||||
| HS TNT, pg/ml | 5 ± 4 | 8 ± 4* | 8 ± 11ll | 0.99 |
| NT-proBNP, pg/ml | 121 ± 118 | 134 ± 274 | 142 ± 177 | 0.68 |
| Hematocrit, % | 37 ± 4 | 35 ± 4‡ | 38 ± 3 | < 0.001 |
| Hb, mg/dl | 12.5 ± 1.1 | 11.6 ± 1.2‡ | 12.6 ± 1.0 | < 0.001 |
| Creatinine, mg/dl | 0.82 ± 0.2 | 0.76 ± 0.14 | 0.83 ± 0.12 | 0.01 |
| Mapping parameters | ||||
| T1, ms | 1244 ± 29 | 1293 ± 34‡ | 1250 ± 26 | < 0.001 |
| T2, ms | 45 ± 3 | 48 ± 3‡ | 46 ± 3 | 0.007 |
| Extracellular volume (%) | 28 ± 2 | 29 ± 2 | ||
| Global LV strain | ||||
| GLS, % | − 18 ± 2 | − 17 ± 2* | − 17 ± 2ll | 0.99 |
| GCS, % | − 18 ± 2 | − 17 ± 3* | − 17 ± 3ll | 0.70 |
| GRS, % | 36 ± 7 | 34 ± 8 | 34 ± 6 | 0.92 |
| Left heart parameters | ||||
| LVEF, % | 60 ± 5 | 60 ± 6 | 60 ± 6 | 0.51 |
| LV mass index, g/m2 | 51 ± 5 | 51 ± 7 | 52 ± 7 | 0.49 |
| LVEDVi, ml/m2 | 76 ± 10 | 72 ± 13† | 76 ± 12 | 0.003 |
| LVESVi, ml/m2 | 30 ± 6 | 29 ± 7 | 31 ± 7 | 0.002 |
| LVSVi, ml/m2 | 46 ± 7 | 43 ± 9* | 45 ± 8 | 0.09 |
| LAESVi, ml/m2 | 34 ± 10 | 30 ± 9† | 34 ± 10 | < 0.001 |
| LAEDVi, ml/m2 | 15 ± 6 | 14 ± 4 | 15 ± 6 | 0.09 |
| Right heart parameters | ||||
| RVEF, % | 56 ± 7 | 58 ± 8 | 58 ± 6 | 0.59 |
| RVEDVi, ml/m2 | 77 ± 11 | 73 ± 14† | 74 ± 13 | 0.41 |
| RVESVi, ml/m2 | 34 ± 8 | 31 ± 9† | 31 ± 6ll | 0.57 |
| RVSVi, ml/ m2 | 43 ± 8 | 43 ± 9 | 43 ± 10 | 0.70 |
| RAESVi, ml/m2 | 35 ± 9 | 30 ± 8‡ | 35 ± 10 | < 0.001 |
| RAEDVi, ml/m2 | 20 ± 6 | 16 ± 5‡ | 17 ± 7¶ | 0.14 |
| Presence of LGE, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Numbers are mean ± SD for continuous and n (%) for categorical data
*p < 0.05, †p < 0.01, or ‡p < 0.001 for baseline vs. FU1
llp < 0.05 or ¶p < 0.01 for baseline vs. FU2
Abbreviations: GCS, global circumferential strain, GLS, global longitudinal strain, GRS, global radial strain; Hb, hemoglobin; HS TNT, high sensitive troponin T; LA, left atrial; LAEDVi, left atrial end-diastolic volume index; LAESVi, left atrial end-systolic volume index; HS TNT, high sensitive troponin T; LGE, late gadolinium enhancement; LV, left ventricular; LVEF, left ventricular ejection fraction; LVEDVi, left ventricular end-diastolic volume index; LVESVi, left ventricular end-systolic volume index; LVSVi, left ventricular stroke volume index; NT-proBNP, N-terminal pro-brain natriuretic peptide; RA, right atrial; RAEDVi, right atrial end-diastolic volume index; RAESVi, right atrial end-systolic volume index; RV, right ventricular; RVEF, right ventricular ejection fraction; RVEDVi, right ventricular end-diastolic volume index; RVESVi, right ventricular end-systolic volume index; RVSVi, right ventricular stroke volume index