Table 3.

Therapy-induced changes of laboratory and CMR parameters with left-sided radiotherapy

	Baseline (n = 27)	FU1 (n = 27)	FU2 (n = 27)	p value for FU1 vs. FU2
Laboratory tests
HS TNT, pg/ml	5 ± 2	6 ± 3*	5 ± 2	0.04
NT-proBNP, pg/ml	98 ± 85	91 ± 73	107 ± 118	0.21
Hematocrit, %	37 ± 3	38 ± 2	38 ± 2	0.62
Hb, mg/dl	12.7 ± 1.0	12.9 ± 0.8	12.7 ± 0.8	0.63
Creatinine, mg/dl	0.77 ± 0.12	0.77 ± 0.09	0.78 ± 0.11	0.56
Mapping
T1, ms	1237 ± 29	1237 ± 42	1239 ± 39	0.80
T2, ms	46 ± 3	47 ± 2	46 ± 3	0.30
Extracellular volume (%)	30 ± 3		30 ± 3
Global LV strain
GLS, %	-18 ± 2	-18 ± 2	-18 ± 1	0.33
GCS, %	-18 ± 2	-18 ± 2	-19 ± 3	0.11
GRS, %	39 ± 6	39 ± 9	39 ± 7	0.90
CMR – left heart
LVEF, %	62 ± 5	64 ± 6	62 ± 5	0.19
LV mass index, g/m2	51 ± 5	52 ± 6	52 ± 6	0.59
LVEDVi, ml/m2	78 ± 10	75 ± 11*	72 ± 11§	0.06
LVESVi, ml/m2	30 ± 6	29 ± 11	27 ± 6	0.34
LVSVi, ml/m2	48 ± 6	48 ± 10	45 ± 7‡	0.05
LAESVi, ml/m2	36 ± 10	34 ± 10	33 ± 10	0.54
LAEDVi, ml/m2	16 ± 7	15 ± 7	15 ± 6	0.89
CMR – right heart
RVEF, %	57 ± 6	58 ± 7	60 ± 7	0.22
RVEDVi, ml/m2	81 ± 11	75 ± 14*	75 ± 15‡	0.99
RVESVi, ml/m2	36 ± 7	32 ± 7†	30 ± 8§	0.28
RVSVi, ml/ m2	45 ± 7	44 ± 10	45 ± 11	0.50
RAESVi, ml/m2	38 ± 12	37 ± 13	38 ± 15	0.61
RAEDVi, ml/m2	21 ± 7	19 ± 8	19 ± 11	0.94
LGE lesions, n (%)	0 (0)	0 (0)	0 (0)	0 (0)

Numbers are mean ± SD for continuous and n (%) for categorical data

^*p < 0.05 or ^†p < 0.01 for baseline vs. FU1

^‡p < 0.05 or ^§p < 0.001 for baseline vs. FU2

Abbreviations: as in Table 2