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. 2021 Oct 6;12(2):522–541. doi: 10.1158/2159-8290.CD-20-1513

Figure 1.

Figure 1. Recurrently mutated genes and UV light–induced global mutation signature in BPDCN. A, Comutation plot of SNVs and indels in BPDCN samples among genes recurrently mutated in other hematologic malignancies. Each column represents an individual patient; genes are in rows and mutation types are annotated by color. Percentages of patients with a given gene altered are plotted to the left. Samples are annotated by gender and sequencing method (WES). B, VAF of all somatic mutations (including synonymous) with VAF ≥0.1 detected by WES in 11 BPDCN plotted as gray dots. VAFs of known hematologic malignancy-related genes from A are annotated in red (autosomes) or blue (X chromosome). C, Global somatic mutational signatures in BPDCN, AML, and melanoma plotted as fraction of samples (x-axis) having a specific signature with the mean signature score in those patients (y-axis). The color of the circle represents a specific signature, and the size of the circle represents the strength of association as a combined measure of the fraction of patients having a signature and the contribution score.

Recurrently mutated genes and UV light–induced global mutation signature in BPDCN. A, Comutation plot of SNVs and indels in BPDCN samples among genes recurrently mutated in other hematologic malignancies. Each column represents an individual patient; genes are in rows and mutation types are annotated by color. Percentages of patients with a given gene altered are plotted to the left. Samples are annotated by gender and sequencing method (WES). B, VAF of all somatic mutations (including synonymous) with VAF ≥0.1 detected by WES in 11 BPDCN plotted as gray dots. VAFs of known hematologic malignancy-related genes from A are annotated in red (autosomes) or blue (X chromosome). C, Global somatic mutational signatures in BPDCN, AML, and melanoma plotted as fraction of samples (x-axis) having a specific signature with the mean signature score in those patients (y-axis). The color of the circle represents a specific signature, and the size of the circle represents the strength of association as a combined measure of the fraction of patients having a signature and the contribution score.