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. 2022 Feb 10;13:805. doi: 10.1038/s41467-022-28378-6

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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Fig. 7 — a–c WT or Vhl-KO SMARTA cells were stained with CFSE, cultured under Tfh-like conditions, and stained and analyzed on d2 or 3 as indicated. d Schematic of HIF-1α-centered negative feedback loops with mTORC1 and Myc, which are also part of a positive feedback loop with each other. Blue: genes promoting Tfh cells; Red: genes inhibiting Tfh cells. Scale represented in legend in the figure. Representative data for (a–c) shown from 1 of at least 2 independent experiments.