Table 2.

Correlation coefficients between microRNA expression and tumor immune microenvironment (immune cell and immune checkpoint) in tumor center and invasive margin.

		Immune cell					Immune checkpoint
		CD3	CD4	CD8	CD68	Foxp3	PD-1	PD-L1
Tumor center	miR-21-5p	− 0.247*	− 0.261*	− 0.238	− 0.127	− 0.145	− 0.256*	− 0.038
	miR-34a-5p	− 0.165	− 0.187	− 0.116	− 0.197	− 0.051	− 0.168	− 0.049
	miR-200a-3p	− 0.143	− 0.156	− 0.208	− 0.24	− 0.087	− 0.069	− 0.143
	miR-200c-3p	− 0.262*	− 0.252*	− 0.293*	− 0.281*	− 0.222	− 0.145	− 0.195
	miR-630	− 0.144	− 0.087	− 0.157	0.264*	0.093	− 0.221	0.056
	miR-1246	− 0.01	0.138	0.007	0.216	− 0.059	0.008	0.152
	miR-1290	− 0.083	0.012	0.033	0.226	0.012	0.069	0.082
Invasive margin	miR-21-5p	− 0.336**	− 0.335**	− 0.351**	− 0.259*	− 0.236	− 0.371**	− 0.21
	miR-34a-5p	− 0.279*	− 0.329**	− 0.273*	− 0.263*	− 0.26*	− 0.261*	− 0.179
	miR-200a-3p	− 0.246*	− 0.277*	− 0.265*	− 0.283*	− 0.246*	− 0.114	− 0.257*
	miR-200c-3p	− 0.293*	− 0.256*	− 0.327**	− 0.251*	− 0.287*	− 0.187	− 0.338**
	miR-630	− 0.153	− 0.1	− 0.193	0.051	0.123	− 0.16	− 0.09
	miR-1246	0.1	0.144	− 0.018	0.047	− 0.015	0.118	0.012
	miR-1290	0.075	0.003	0.07	0.135	0.059	0.212	0.031

Data are presented as Spearman’s correlation coefficient.

*P-value < 0.05, **P-value < 0.01.