Table 3.
Relationship between the concentration of tissue microRNA-21-5p, 200c-3p, and plasma microRNA-1290 and clinicopathologic features.
| Variable | T-miR-21-5p | T-miR-200c-3p | P-miR-1290 | |||
|---|---|---|---|---|---|---|
| Median (range) | P value | Median (range) | P value | Median (range) | P value | |
| (104 × copies/ng) | (104 × copies/ng) | (copies/µL) | ||||
| Sex | 0.198 | 0.182 | 0.548 | |||
| Male | 6.42 (0.909–99.9) | 2.205 (0.222–22.53) | 2.25 (0.617–8.1) | |||
| Female | 8.76 (0.903–41.82) | 3.45 (0.195–10.47) | 1.73 (0.837–7.067) | |||
| Tumor size | 0.795 | 0.358 | 0.369 | |||
| < 5 cm | 8.385 (0.903–75.39) | 2.124 (0.195–10.47) | 1.85 (0.653–8.1) | |||
| ≥ 5 cm | 7.2 (1.413–99.9) | 2.496 (0.222–22.53) | 2.43 (0.617–6.533) | |||
| Histologic grade | 0.170 | 0.774 | 0.117 | |||
| WD | 4.11 (0.909–12.48) | 2.711 (0.393–8.91) | 1.258 (0.837–6.433) | |||
| MD | 8.37 (0.903–99.9) | 2.43 (0.195–22.53) | 2.067 (0.617–8.1) | |||
| PD | 11.28 (0.975–41.82) | 2.385 (0.339–10.47) | 3.233 (1.733–5.933) | |||
| Lymphatic invasion | 0.002** | < 0.001** | 0.884 | |||
| Absent | 6.06 (0.903–75.39) | 1.809 (0.195–8.91) | 2.067 (0.617–8.1) | |||
| Present | 13.305 (3.06–99.9) | 5.34 (0.234–22.53) | 2.067 (0.75–5.933) | |||
| Venous invasion | 0.204 | 0.094 | 0.469 | |||
| Absent | 7.98 (0.903–89.4) | 2.28 (0.195–11.01) | 1.933 (0.617–8.1) | |||
| Present | 10.23 (2.97–99.9) | 5.235 (0.228–22.53) | 2.33(0.75–6.533) | |||
| Perineural invasion | 0.068 | 0.941 | 0.426 | |||
| Absent | 7.05 (0.903–60.48) | 2.295 (0.195–9.6) | 2.1 (0.617–7.067) | |||
| Present | 10.23 (1.107–99.9) | 2.493 (0.222–22.53) | 1.833(0.75–8.1) | |||
| TNM staging | 0.010** | 0.007** | < 0.001** | |||
| I | 6.27 (0.903–60.48) | 1.398 (0.36–8.91) | 1.23 (0.653–4.067) | |||
| II | 5.595 (1.107–28.02) | 1.737 (0.195–6.24) | 3.7 (1.223–8.1) | |||
| III | 10.92 (0.975–41.82) | 2.285 (0.228–9.6) | 1.4 (0.617–6.533) | |||
| IV | 12.21 (5.52–99.9) | 5.79 (0.24–22.53) | 2.287 (0.75–5.733) | |||
| Location | 0.577 | 0.022* | 0.667 | |||
| Right | 6.885 (0.975–41.82) | 5.55 (0.339–10.47) | 2.117 (0.837–5.933) | |||
| Left/rectum | 8.4 (0.903–99.9) | 2.13 (0.195–22.53) | 1.933 (0.617–8.1) | |||
| KRAS | 0.665 | 0.943 | 0.431 | |||
| Wild | 8.175 (0.909–89.4) | 2.204 (0.225–11.01) | 1.683 (0.653–8.1) | |||
| Mutant | 8.28 (0.903–99.9) | 2.76 (0.195–22.53) | 2.1 (0.617–7.067) |
Data are presented as Median (range).
*P-value < 0.05, **P-value < 0.01.
T-, tissue; P- plasma.
SD standard deviation, WD well differentiated, MD moderately differentiated, PD poorly differentiated.