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. 2022 Feb 10;13:800. doi: 10.1038/s41467-022-28343-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Clinical photos of two patients with a missense and nonsense (LOF) variant in KRT82, respectively. Both show hair loss patterns characteristic of AA. b Immunohistochemistry (IHC) staining of CD8+ T cells in 4 patients with missense variants in KRT82. Perifollicular CD8+ T cell infiltrate is a diagnostic characteristic of AA. Each biopsy shown is taken from an individual with AA, serving as 4 biological replicates. c RNA expression profiles of the ALADIN (Alopecia Areata Disease Severity Index) inflammatory signature confirms that three patients (green bars) with KRT82 variants (splice and missense) have increased expression of the inflammatory signature, characteristic of AA. Additionally, these three KRT82-carrying patients (green) cluster within AA patients (AAP-red, ATAU-orange), and not with controls (blue).