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. 2022 Feb 10;5:123. doi: 10.1038/s42003-022-03059-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–f Vesicle permeabilization by truncated αSN constructs. Permeabilization assays with truncated αSN monomers (a, b), unmodified αSOs (c, d), and ONE-modified αSN monomers (e, f) shows more aggressive behavior for oligomers in comparison to monomers, however, ONE-αSO121 and the shorter ones are not as aggressive as the ONE-αSO125 and longer oligomers. g, h Cell viability with 10 µM oligomer confirms the results of vesicle permeabilization. In h αSOs of αSN121 and longer variants are binned into one group and αSN115 and shorter variants into another. Cell toxicity of each group was compared by ANOVA (in graph pad software). ***p-value ≤ 0.001. Each point is the average of three repeats for permeabilization or four repeats for cell toxicity where error bars show standard deviation. Error bars for h show 95% CI.